Methylotrophs are ubiquitous in nature and found in a variety of environments including air, water, soil, plant and drive the carbon cycle through interaction with neighboring organisms such as plants and bacteria. Plants provide methylotrophs with habitats as well as compounds including growth substrates. Plant and methylotrophic bacterial interactions that improve plant growth and plant fitness are becoming a topic of very important considerable interest. Among methylotrophic microorganisms, methylotrophic bacteria occupy the surface of leaves and stems as well as internal tissues such as root nodules of plants without causing the disease to their hosts. The exact population and the composition of the methylotrophic bacteria depend upon biotic and abiotic factors
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