Combinatorial Genetic Logic - Cox, Robert Sidney
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This book examines several synthetic transcriptional regulatory circuits in bacteria. Chapter 1 presents a novel technique for shuffling short sequences of regulatory DNA to generate exponential libraries of functional sequences. Chapter 2 introduces a library of combinatorial promoters--genetic logic gates which integrate multiple environmental signals. Chapter 3 examines the role of genetic noise in transcriptional co-regulation using a three-color fluorescent reporter system. Chapter 4 showcases a synthetic circuit for the control of population density in a bacterial growth culture. These…mehr

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Produktbeschreibung
This book examines several synthetic transcriptional regulatory circuits in bacteria. Chapter 1 presents a novel technique for shuffling short sequences of regulatory DNA to generate exponential libraries of functional sequences. Chapter 2 introduces a library of combinatorial promoters--genetic logic gates which integrate multiple environmental signals. Chapter 3 examines the role of genetic noise in transcriptional co-regulation using a three-color fluorescent reporter system. Chapter 4 showcases a synthetic circuit for the control of population density in a bacterial growth culture. These examples highlight a quantitative approach for characterizing the logical input functions of prokaryotic genes, focusing on the relationship between combinatorial promoter functions and architectures.
Autorenporträt
Spent his youth catching snakes around the swamps and rivers of Tallahassee, Florida. He received a Bachelor's in Physics, Chemistry and Mathematics from New College, the Honors College of Florida. While living in Los Angeles he completed the present work and was awarded a Doctorate in Biology from CalTech. Dr. Cox now resides in Tokyo.