Raimo Pohjanvirta

The Ah Receptor in Biology and Toxicology

• Gebundenes Buch

Produktbeschreibung

This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.

---

Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons / Wiley
• Seitenzahl: 552
• Erscheinungstermin: 20. Dezember 2011
• Englisch
• Abmessung: 282mm x 216mm x 30mm
• Gewicht: 1451g
• ISBN-13: 9780470601822
• ISBN-10: 0470601825
• Artikelnr.: 33762858

Autorenporträt

Raimo Pohjanvirta, PhD, is Professor of Toxicology at the University of Helsinki. He has been studying the effects and action mechanisms of dioxins for over twenty years, publishing over a hundred peer-reviewed papers on dioxins and AHR. Dr. Pohjanvirta has been an invited lecturer at major international conferences, including the Society of Toxicology, EUROTOX, and the British Toxicology Society.

Inhaltsangabe

Preface.
A. Historical background.
1. History of Research on the AHR (Thomas A. Gasiewocz and Ellen C. Henry
).
B. AHR as a ligand-activated transcription factor.
2. Overview of AHR functional domains and the classical signaling pathway:
induction of drug-metabolizing enzymes (Qiang Ma).
3. Role of chaperone proteins in AHR function (Iain A. Murray and Gary H.
Perdew).
4. AHR Ligands: Promiscuity in Binding and Diversity in Response (Danica
DeGroot, Guochun He, Domenico Fraccalvieri, Laura Bonati, Allesandro Pandin
and Michael S. Denison).
5. Dioxin response elements and regulation of gene transcription (Hollie
Swanson).
6. The AHR/ARNT dimer and transcriptional coactivators (Oliver Hankinson).
7. Regulation of AHR by the AHR repressor (AHRR) (Yoshiaki Fujii-Kuriyama
and Kaname Kawajiri).
8. Influence of HIF-1¿ and Nrf2 signaling on AHR-mediated gene expression,
toxicity and biological functions (Thomas Haarmann-Stemmann and Josef Abel
).
9. Functional interactions of AHR with other receptors (Sara Brunnberg,
Elin Swedenborg and Jan-Åke Gustafsson).
10. The E3 ubiquitin ligase activity of transcription factor AHR permits
non-genomic regulation of biological pathways (Fumiaki Ohtake and Shigeaki
Kato).
11. Epigenetic mechanisms in AHR function (Chia-I Ko and Alvaro Puga).
C. AHR as a mediator of xenobiotic toxicities: dioxins as a key example.
12. Role of the AHR and its structure in TCDD toxicity (Raimo Pohjanvirta,
Merja Korkalainen, Ivy D. Moffat, Paul C. Boutros, Allan B. Okey).
13. Nongenomic route of action of TCDD: Identity, characteristics and
toxicological significance (Fumio Matsumura).
14. Inter-species heterogeneity in the hepatic transcriptomic response to
AHR activation by dioxin (Paul Boutros).
15. Dioxin-activated AHR: toxic responses and the induction of oxidative
stress (Sidney J. Stohs and Ezdihar A. Hassoun).
16. Dioxin-activated AHR and cancer in laboratory animals (Dieter Schrenk
and Martin Chopra).
17. Teratogenic impact of dioxin-activated AHR in laboratory animals (
Barbara D. Abbott).
18. The developmental toxicity of dioxin to the developing male
reproductive system in the rat; relevance of the AHR for risk assessment (
David R. Bell).
19. TCDD, AHR and immune regulation (Nancy I. Kerkvliet).
20. Effects of dioxins on teeth and bone: the role of AHR (Matti Viluksela,
Hanna M. Miettinen and Merja Korkalainen).
21. Impacts of dioxin-activated AHR signaling in fish and birds (Michael T.
Simonich and Robert L. Tangray).
22. Adverse Health Outcomes Caused By Dioxin-Activated AHR in Humans (
Sally S. White, Suzanne E. Fenton, and Linda S. Birnbaum).
23. The toxic equivalency principle and its application in dioxin risk
assessment (Jouko Tuomisto).
24. AHR-active compounds in the human diet (Stephen Safe, Gayathri
Chadalapaka and Indira Jutooru).
25. Modulation of AHR function by heavy metals and disease states (Anwar
Anwar-Mohammed and Ayman O.S. El-Kadi).
26. Transgenic mice with a constitutively active AHR: a model for human
exposure to dioxin an other AHR ligands (Patrik Andersson, Sara Brunnberg,
Carolina Wejheden, Lorenz Poellinger and Annika Hanberg).
D. AHR as a physiological regulator.
27. Structural and functional diversification of AHRs during metazoan
evolution (Mark E. Hahn and Sibel I. Karchner).
28. Invertebrate AHR homologs: Ancestral functions in sensory systems (Jo
Anne Powell-Coffman and Hongtao Qin).
29. Role of AHR in the development of the liver and blood vessels (Sahoko
Ichihara).
30. Involvement of the AHR in cardiac function and regulation of blood
pressure (Jason A. Scott and Mary K. Walker).
31. Involvement of the AHR in development and functioning of the female and
male reproductive systems (Bethany N. Karman, Isabel Hernández-Ochoa,
Ayelet Ziv-Gal, Jodi A. Flaws).
32. The AHR in the control of cell cycle and apoptosis (Cornelia Dietrich
).
33. The AHR regulates cell adhesion and migration by interacting with
oncogene and growth factor-dependent signaling (Angel Carlos Roman, Jose M.
Carvajal-Gonzalez, Sonia Mulero-Navarro, Aurea Gomez-Duran, Eva M. Rico-Leo
and Pedro M. Fernandez-Salguero).
34. The physiological role of AHR in the mouse immune system (Charlotte
Esser).
35. AHR and the circadian clock (Shelley A. Tischkau).