Ralph Rapley / Stuart Harbron

Molecular Analysis and Genome Discovery

Ed. by Ralph Rapley and Stuart Harbron

• Broschiertes Buch

Produktbeschreibung

This advanced level textbook provides a comprehensive overview of recent developments in the area of molecular based diagnostics of disease markers. Coverage includes: the impact of techniques such as in vitro nucleic acid amplifications and other amplification methods, gene and biochip production, automated techniques such as fluorescent sequencing, and key concepts and elements where new and merging areas are being researched and developed, including pharmacogenomics, proteomics, and functional genomics. In addition, examples are given where this new area of bioscience has or may be successfully applied.

Produktdetails

• Verlag: Wiley & Sons
• Seitenzahl: 388
• Englisch
• Abmessung: 245mm
• Gewicht: 674g
• ISBN-13: 9780471499190
• ISBN-10: 0471499196
• Artikelnr.: 14918295

Autorenporträt

R. Rapley, University of Hertfordshire; S. Harbron, Zetratronics Ltd

Inhaltsangabe

Preface.

List of Contributors

1. Pharmacogenetics and Pharmacogenomics: An Overview (W. Kalow).

2. Quantitative TaqMan Real-time PCR: Diagnostic and Scientific Applications (Jörg Dötsch, Ellen Schoof and Wolfgang Rascher).

3. Hybridization Probes for Real-time PCR (Elaine Lyon).

4. An Overview of Genotyping and Single Nucleotide Polymorphisms (SNP) (Ivo Glynne Gut).

5. High-throughput Mutation Screening (Paal Skytt Andersen and Lars Allan Larsen).

6. Determination of Nucleic Acid Sequence by Pyrosequencing (Elaine Elahi and Mostafa Ronaghi).

7. An Introduction to DNA Chips (Magdalena Gabig-Ciminska and Andrzej Ciminski).

8. Overview of Microarrays in Genomic Analysis (Janette K Burgess).

9. Overview of Differential Gene Expression by High-throughput Analysis (Kin-Ying To).

10. Aptamers: Powerful Molecular Tools for Therapeutics and Diagnostics (Eva Baldrich i Rubio, Mònica Campàs i Homs and Ciara K. O'Sullivan).

11. Chip-based Proteomics Technology (Mikhail Soloviev, Richard Barry and Jon Terrett).

12. Infectomics Overview: Holistic and Integrative Studies of Infectious Diseases (Sheng-He Huang and Ambrose Jong).

13. The Drug Discovery Process (Roberto Solari).

14. Structure-based Drug Discovery (Chen-Chen Kan, Kevin Hambly and Derek A. Debe).

15. Protein Interaction-targeted Drug Discovery (Gary Hudes, Sanjay Menon and Erica A. Golemis).

16. Overview of Quantitative Structure-Activity Relationships (QSAR)(David A. Winkler).

Index.