Iran is the third biggest potato producer in Asia where the production is more than 5 million t with average of 25 t per ha. In comparison with the other crops, potato is sensitive to water stress and irrigation has become an essential component of potato production in arid and semiarid regions. Therefore, this research was conducted to investigate potato cultivar Santeh yield and water use efficiency responses to full and deficit irrigation in Hamadan, Iran. Soil and water researchers, engineers and students can use findings of this study.