Current statistics of Diabetes Atlas of International Diabetes Federation, states 285 million among the world population suffer from Diabetes mellitus. It is a non-communicable disease and oxidative stress due to the rapid formation of free radicals and protein glycation are the key molecular basis of macro and micro complications of diabetes mellitus. There is a global clamor to use herbal treatments in Diabetes mellitus due to the minimal adverse effects, safety and low cost., but very few scientific investigations have been carried out to prove the efficacy of using these herbal plants in the treatment of Diabetes mellitus. This study covers five medicinal plants commonly used in the treatment of diabetes mellitus by gathering information from the traditional and Ayurveda medical practitioners and their antiglycation,antioxidant potentias and phenolic contents. The selected herbal plant parts are Cassia auriculata flowers, Osbakia octandra leaves, Syzygium cumini bark, Phyllanthus emblica fruits and Scoparia dulcis whole plant. These are administrated as decoctions of poly herbal formulations and as individual plants, prepared according to the Ayurveda pharmacopeia.