Tectona Grandis - A Useful Herb - Bhangale, Jitendra;Chaudhari, S. R.;Acharya, S. R.
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The aqueous extract of Tectona grandis bark (ATG) was investigated for anti-inflammatory and antinociceptive activity at the doses (p.o.) of 100, 200 and 400 mg/kg body weight. The acetic acid-induced writhing response, tail immersion test and hot plate test were used to assess antino-ciceptive activity. For evaluation of anti-inflammatory activity, carrageenan induced paw edema served as acute model. At a dose, ATG (100, 200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and at ATG (200 and 400 mg/kg, p.o.)…mehr

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Produktbeschreibung
The aqueous extract of Tectona grandis bark (ATG) was investigated for anti-inflammatory and antinociceptive activity at the doses (p.o.) of 100, 200 and 400 mg/kg body weight. The acetic acid-induced writhing response, tail immersion test and hot plate test were used to assess antino-ciceptive activity. For evaluation of anti-inflammatory activity, carrageenan induced paw edema served as acute model. At a dose, ATG (100, 200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and at ATG (200 and 400 mg/kg, p.o.) significantly increased pain latencies in tail immersion and hot plate test. In addition, the higher doses of ATG (200 and 400 mg/kg, p.o.) were inhibited carrageenan induced paw edema. From acute oral toxicity studies (OECD-423 guidelines), no mortality was observed even at highest dose of ATG (2000 mg/kg, p.o.).
Autorenporträt
Jitendra O. Bhangale (M.Pharma. DIPL) working as Head, Department of Pharmacology, Smt. N. M. Padalia Pharmacy College, Ahmedabad, Gujarat, India and pursuing Ph.D. in Pharmaceutical Sciences.Dr. Sanjeev R. Acharya (M.Pharma. Ph.D.) working as Associate Professor at Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.