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Condylar growth modification is induced by orthodontic mandibular advancement; though the changes in temporomandibular joint (TMJ) after mandibular advancement by fixed orhodontic myofunctional appliance could be permanently stable is not yet proved. Therefore, our purpose is to investigate the effects of mandibular advancement on the rat TMJ by changing in matrix metalloproteinases (MMPs) and collagens (COLs)expression immunohistochemically (IHC) after retentiontreatment.