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this book include complete description of a practical study done to reveal correlation between serum resistin levels with insulin resistance and severity of microangiopathy in type II diabetes mellitus. this book also try to declare debates arising about: Obesity and its relation to type II dabetes mellitus. Could resistin (the newly discovered hormone)be a link between obesity and type II diabetes mellitus? Relation between resistin and retinopathy, one of the most compromising diabetic complications.