Andere Kunden interessierten sich auch für
![Synthesis and Reactivity of Donor-Acceptor Substituted Aminocyclopropanes and Aminocyclobutanes]( "Synthesis and Reactivity of Donor-Acceptor Substituted Aminocyclopropanes and Aminocyclobutanes")
Synthesis and Reactivity of Donor-Acceptor Substituted Aminocyclopropanes and Aminocyclobutanes74,99 €![A Novel Heme-Thiolate Peroxygenase AaeAPO and Its Implications for C-H Activation Chemistry]( "A Novel Heme-Thiolate Peroxygenase AaeAPO and Its Implications for C-H Activation Chemistry")
A Novel Heme-Thiolate Peroxygenase AaeAPO and Its Implications for C-H Activation Chemistry74,99 €![Heteroaromatic Lipoxin A4 Analogues]( "Heteroaromatic Lipoxin A4 Analogues")
Heteroaromatic Lipoxin A4 Analogues74,99 €![Total Synthesis of (±)-Maoecrystal V]( "Total Synthesis of (±)-Maoecrystal V")
Total Synthesis of (±)-Maoecrystal V74,99 €![Total Synthesis of (±)-Maoecrystal V]( "Total Synthesis of (±)-Maoecrystal V")
Total Synthesis of (±)-Maoecrystal V74,99 €![Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B]( "Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B")
Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B74,99 €![Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53]( "Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53")
Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p5337,99 €
This work describes novel, effective hydrogen-bond (HB) donor catalysts based on a known bifunctional tertiary amine-thiourea, a privileged structure, which has been proven to be one of the most widely used organocatalysts. These HB donor catalysts derived from quinazoline and benzothiadiazine were initially synthesized as novel HB donors with their HB-donating abilities being measured by analytical methods. They were found to be effective for a variety of asymmetric transformations including Michael reactions of a, b-unsaturated imides and hydrazination reactions of 1,3-dicarbonyl compounds. Thiourea catalysts that have an additional functional group are also described. Specifically, thioureas that bear a hydroxyl group were synthesized and subsequently used as novel bifunctional organocatalysts for catalytic, asymmetric Petasis-type reactions involving organoboronic acids as nucleophiles. These addition reactions were difficult to achieve using existing organocatalysts. One of the developed catalytic methods can be applied to the synthesis of biologically interesting peptide-derived compounds possessing unnatural vinyl glycine moieties. These findings introduce new criteria required for the development of organocatalysts for asymmetric reactions, thus making a significant contribution to the field of organocatalysis.