Physicochemical characterization & dissolution studies of Allopurinol - Musale, Vinod
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The rate-limiting step to absorption of drugs from the gastrointestinal tract is often dissolution from the dosage form. Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with leukaemia, radiotherapy. One of the major problems with allopurinol is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study amphiphilic carrier like gelucire 50/13, PVP K30 & PEG 6000 are used in the ratio of 1:1, 1:2 and 1:4. Prepared solid dispersions were characterized in the liquid state by…mehr

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Produktbeschreibung
The rate-limiting step to absorption of drugs from the gastrointestinal tract is often dissolution from the dosage form. Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with leukaemia, radiotherapy. One of the major problems with allopurinol is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study amphiphilic carrier like gelucire 50/13, PVP K30 & PEG 6000 are used in the ratio of 1:1, 1:2 and 1:4. Prepared solid dispersions were characterized in the liquid state by phase solubility studies and in the solid state by Differential Scanning calorimetric analysis, Powder X-ray diffractometry and Fourier Transform Infrared spectroscopy. The aqueous solubility of allopurinol was preferential by the presence polymer with increasing concentration. Solid state characterizations indicated that allopurinol was present as an amorphous material and entrapped in polymermatrix. Therefore, the current Research showed that gelucire 50/13 PVP K30 & PEG 6000 has a significant solubilizing effect on allopurinol.
Autorenporträt
Vinod Musale,Vinod Born Aug 19,1984),Research Scholar & Scientist at Medisol Lifescience Pvt. Ltd., Gujarat (India),Vinod has earned Masters of Pharmacy (Quality Assurance)University of Pune on 2009 and stood 1st class all through academic results.Vinod has extensive exposer in P'ceutical Quality Assurance & Regulatory Affairs.