Yitayal Admassu Workie

Chemometrics assisted spectrophotometeric determination

Of certain pharmaceuticals containing candesartan cilexetil and hydrochlorothiazide

• Broschiertes Buch

Produktbeschreibung

Combination (consist of drugs, two or more, combined in a unique formulation) antihypertensives include combined agents from the different pharmacologic classes. More recently, a very new combination dosage form of candesartan cilexetil and hydrochlorothiazide (from the class of angiotensin-II antagonists and diuretics) is indicated in the treatment and management hypertension. Simultaneous determination of candesartan cilexetil and hydrochlorothiazide mixtures by using spectrophotometric method is a difficult problem in analytical chemistry, due to spectral interferences. UV-spectra of studied drugs were collected from 200nm to 350nm in ethanolic solutions. In this range the studied drugs showed a considerable degree of spectral overlapping (91.82%). Initial studies of the UV-spectra of the individual compounds showed that satisfactory linear regression calibration models could be constructed in the concentration range of 5-50¿g/ml and 2-20¿g/ml for candesartan and hydrochlorothiazide respectively.

Produktdetails

• Verlag: LAP LAMBERT Academic Publishing
• Seitenzahl: 80
• Erscheinungstermin: 29. Oktober 2019
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 137g
• ISBN-13: 9786202093453
• ISBN-10: 6202093455
• Artikelnr.: 62455067

Autorenporträt

Yitayal Admassu Workie - PhD Candidate, National Taiwan University of Science and Technology · Graduate Institute of Applied Science and Technology.