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A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or…mehr
A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.
Synthesis of Indole Derivatives Construction of 2-(Aminomethyl)indoles through Copper-Catal¬yzed Domino Three-Component Coupling and Cyclization Facile Synthesis of 1,2,3,4-Tetrahydro-β-carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling–Cyclization–N-Arylation under Microwave Irradiation Synthesis of Isoquinoline Derivatives Facile Synthesis of 3-(Aminomethyl)isoquinolines by Copper-Catalyzed Domino Four-Component Coupling and Cyclization Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclization, and Oxidation Conclusions Acknowledgements
Synthesis of Indole DerivativesConstruction of 2-(Aminomethyl)indoles through Copper-Catal¬yzed Domino Three-Component Coupling and CyclizationFacile Synthesis of 1,2,3,4-Tetrahydro-beta-carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic CyclizationConcise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling-Cyclization-N-Arylation under Microwave IrradiationSynthesis of Isoquinoline DerivativesFacile Synthesis of 3-(Aminomethyl)isoquinolines by Copper-Catalyzed Domino Four-Component Coupling and CyclizationRapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclization, and OxidationConclusionsAcknowledgements
Synthesis of Indole Derivatives Construction of 2-(Aminomethyl)indoles through Copper-Catal¬yzed Domino Three-Component Coupling and Cyclization Facile Synthesis of 1,2,3,4-Tetrahydro-β-carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling–Cyclization–N-Arylation under Microwave Irradiation Synthesis of Isoquinoline Derivatives Facile Synthesis of 3-(Aminomethyl)isoquinolines by Copper-Catalyzed Domino Four-Component Coupling and Cyclization Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclization, and Oxidation Conclusions Acknowledgements
Synthesis of Indole DerivativesConstruction of 2-(Aminomethyl)indoles through Copper-Catal¬yzed Domino Three-Component Coupling and CyclizationFacile Synthesis of 1,2,3,4-Tetrahydro-beta-carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic CyclizationConcise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling-Cyclization-N-Arylation under Microwave IrradiationSynthesis of Isoquinoline DerivativesFacile Synthesis of 3-(Aminomethyl)isoquinolines by Copper-Catalyzed Domino Four-Component Coupling and CyclizationRapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclization, and OxidationConclusionsAcknowledgements
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