Effect of Anti diabetic Drugs on Glucose-6-phosphatase Activity in Pa

Effect of Anti diabetic Drugs on Glucose-6-phosphatase Activity in Pa

Glucose-6-phosphatase Activity in Patients with Type 2 Diabetes Mellitus

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Type 2 Diabetes mellitus is a disease characterized by chronically elevated blood glucose levels, even when fasting largely due to increased endogenous glucose production. In liver, glucose-6-phosphatase catalyses the terminal step of glycogenolysis and gluconeogenesis. The classical role of glucose-6-phosphatase in the liver is the production of glucose for release into the blood. This correlation between type 2 diabetes and glucose-6-phosphatase makes this enzyme an appealing drug target for control of blood glucose levels as its inhibition would directly prevent the release of free glucose ...