Can Changes in SR Protein Acetylation Affect Alternative Splicing?
Heather E. Knupp
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Can Changes in SR Protein Acetylation Affect Alternative Splicing?

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Cellular phenotype and function is determined by the cellular proteome. Within the cellular proteome there are processes that have a potential to significantly alter the composition of the proteome. One such process is called alternative splicing. Splicing is the removal of introns from a pre-mRNA sequence and the remaining pre-mRNA sequences, called exons, are combined. Alternative splicing modifies the intron-exon combination, and can form novel products from the different arrangement of the coding sequences. The misreguation of alternative splicing has been documented in many human diseases...