Effects of Chronic Mild Stress on the Cardiovascular System in Rats - Matheka Wambua, Cyrus;Frederick, Bukachi;T.N., Kiama
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Non Communicable Diseases are currently the leading cause of morbidity and mortality in the in the world. Their risk factors are smoking, excessive alcohol intake, physical inactivity, poor diet and psychosocial stress among others. Psychosocial stress induces release of noradrenaline which binds to 1 and -adrenergic receptors, leading to the recruitment G proteins which activate Ras via phosphatidylinositol 3-kinase and subsequently its effector kinase Raf. Raf phosphorylates mitogen extracellular kinases -1 and -2. Additionally, Ras directly induce p38-MAPK activation. Activated MAPKs…mehr

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Produktbeschreibung
Non Communicable Diseases are currently the leading cause of morbidity and mortality in the in the world. Their risk factors are smoking, excessive alcohol intake, physical inactivity, poor diet and psychosocial stress among others. Psychosocial stress induces release of noradrenaline which binds to 1 and -adrenergic receptors, leading to the recruitment G proteins which activate Ras via phosphatidylinositol 3-kinase and subsequently its effector kinase Raf. Raf phosphorylates mitogen extracellular kinases -1 and -2. Additionally, Ras directly induce p38-MAPK activation. Activated MAPKs induces phosphorylation and subsequent degradation of the nuclear factor kappa (NF- B)-specific cytoplasmic inhibitor IkappaBalpha (I B ). This leads to activation and nuclear translocation of NF- B which causes up-regulation of stable cell adhesion molecules that activate monocyte adhesion to the endothelium (ICAM-1 and VCAM-1). The up-regulation of the primary initiation of the serine proteases cascade of the coagulation system in turn promotes thrombosis. This study investigated the electrocardiographic changes in chronic mild stress in male Sprague dawley rats.
Autorenporträt
Cyrus has interests in Non Communicable Diseases research.He holds an Honours Degree in Medical Physiology from the University Of Nairobi besides being a trained accountant.He has served as an editor for the Federation of Africa Medical Students journal and is currently attached to the Africa Mental Health Foundation in Nairobi, Kenya.