Effects of microtubule-interfering agents on AhR signalling - Vrzal, Radim
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Microtubule-interfering agents are compounds which affect microtubules network. They found use in cancer therapy (vinblastine, paclitaxel) or as anti-inflammatory agents (colchicine). Present work focuses on the effect of these compounds in signalling of aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor regulating expression of many genes, some of them being involved in biotransformation of carcinogens.

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Produktbeschreibung
Microtubule-interfering agents are compounds which affect microtubules network. They found use in cancer therapy (vinblastine, paclitaxel) or as anti-inflammatory agents (colchicine). Present work focuses on the effect of these compounds in signalling of aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor regulating expression of many genes, some of them being involved in biotransformation of carcinogens.
Autorenporträt
Radim Vrzal,received his PhDs from Palacky University in Olomouc (Czech Republic) and Université Montpellier 1 (France). Now, he is an associate professor at Palacky University. His research is focused on drug metabolism, biological activity of natural compounds, biotransformation enzymes and their regulation by nuclear receptors.