The study was conducted during the 2021 Kharif season at the student instructional field of the Department of Agronomy, School of Agriculture, ITM University, Gwalior (M.P.). The aim was to assess the impact of conventional and nano-fertilizers on sesame productivity, quality, plant growth parameters, yield attributes, yield, and the economic aspects of sesame cultivation. The soil in the experimental field had a sandy clay loam texture, neutral reactivity to normal electrical conductivity (EC), and medium organic carbon (OC), nitrogen (N), phosphorus (P), and potassium (K) content.