Introduction.- Biochips: technologies and trends.- Digital microfluidic biochips.- Biochip architecture models.- Biochemical application programming and applications models.- Design methodology: the compilation and synthesis problems.- State-of-the-art research on compilation and synthesis.- Module-based compilation with reconfigurable operation execution.- Routing-based compilation.- Compilation for error recovery.- Synthesis of fault-tolerant architectures.- Synthesis of application-specific architectures.- Benchmarks and evaluation.- Conclusions and future work directions.