FORMULATION AND IN-VITRO EVALUATION OF FLOATING TABLET OF GABAPENTIN - Kar, Nihar Ranjan;Mahapatra, Santosh Kumar;Pothal, Rajesh Kumar
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The present research work is an attempt to formulate rate controlled drug delivery system of Gabapentin which is primarily absorbed from stomach, so by increasing the GRT of the drug, the bioavailability can be increased. As the drug is stable in acidic pH and mostly absorbed with in pH 1-3, as the stomach is the major absorption site for the drug. Basing on this fact the drug is made to float in the stomach using the mechanism of buoyancy. The study also includes various evaluation studies of Gabapentin tablet and the effect of processing variables on it. A possible interaction between drug…mehr

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Produktbeschreibung
The present research work is an attempt to formulate rate controlled drug delivery system of Gabapentin which is primarily absorbed from stomach, so by increasing the GRT of the drug, the bioavailability can be increased. As the drug is stable in acidic pH and mostly absorbed with in pH 1-3, as the stomach is the major absorption site for the drug. Basing on this fact the drug is made to float in the stomach using the mechanism of buoyancy. The study also includes various evaluation studies of Gabapentin tablet and the effect of processing variables on it. A possible interaction between drug and polymers are also investigated by FTIR and DSC studies. So, the present work has been under taken with the objective of designing and evaluation of floating oral sustained release tablet drug delivery system of Gabapentin by using HPMC K15, NaCMC, Xanthun gum, sodium bicarbonate, citric acid. Lactose, ethyl cellulose etc.
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Autorenporträt
This is my project work of Master in Pharmacy in Pharmaceutics in Gayatri college of Pharmacy,Sambalpur,Odisha,India.My research guide was Prof.(Dr.)Santosh Kumar Mahapatra,Principal that time and Senior Lecturer in pharmaceutics Mr. rajesh Kumar Pothal.It is my dedicated work to obtain the final project which was helped by other collegues also.