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Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are widely used laboratory markers of systemic inflammation. A thorough understanding of the similarities and differences between these two serological markers, including factors that affect measurements, is necessary for the proper utilization and interpretation of ESR and CRP. This book covers the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two commonly ordered laboratory tests that may aid clinicians in accurately diagnosing the complex disease states. Although these tests have a low index of specificity and are influenced by numerous disease factors, they may provide the clinician with valuable information and additional focus when used in conjunction with other clinical and diagnostic data.