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Produktbild: Impact of Engineered Nanomaterials in Genomics and Epigenomics

Impact of Engineered Nanomaterials in Genomics and Epigenomics

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

22.05.2023

Herausgeber

Saura C. Sahu

Verlag

John Wiley & Sons

Seitenzahl

448

Maße (L/B/H)

40,4/20,7/12,8 cm

Gewicht

765 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-89622-7

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

22.05.2023

Herausgeber

Saura C. Sahu

Verlag

John Wiley & Sons

Seitenzahl

448

Maße (L/B/H)

40,4/20,7/12,8 cm

Gewicht

765 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-89622-7

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Impact of Engineered Nanomaterials in Genomics and Epigenomics
  • Contents
     
    List of Contributors xv
     
    Preface xix
     
    Acknowledgments xxi
     
    1 Impact of Engineered Nanomaterials in Genomics and Epigenomics 1
     
    Saura C. Sahu Contents
     
    Nanotechnology: A Technological Advancement of the Twenty-First Century 1
     
    Genomics and Epigenomics 1
     
    Beneficial Impacts of Engineered Nanomaterials on Human Life 2
     
    Potential Adverse Health Effects of Engineered Nanomaterials 2
     
    Conclusions 3
     
    References 3
     
    2 Molecular Impacts of Advanced Nanomaterials at Genomic and Epigenomic Levels 5
     
    Kamran Shekh, Rais A Ansari, Yadollah Omidi, and Saghir A. Shakil
     
    Introduction 5
     
    Classification of NMs 6
     
    Absorption and Distribution of NMs 6
     
    Major Adverse Effects of NMs 8
     
    Known Cellular and Nuclear Uptake Mechanisms for Nanoparticles 10
     
    Epigenetic Mechanisms and the Effect of NMs 11
     
    DNA Methylation 12
     
    Genetic and Genomic Effects of NMs 20
     
    Conclusion 25
     
    References 26
     
    3 Endocrine Disruptors: Genetic, Epigenetic, and Related Pathways 41
     
    Rais A. Ansari, Saleh Alfuraih, Kamran Shekh, Yadollah Omidi, Saleem Javed, and Saghir A. Shakil
     
    Introduction 41
     
    Toxic Effects of EDCs on Wildlife and Humans 47
     
    Effects During Development 48
     
    Delayed Effects 48
     
    Transgenerational Effects 49
     
    Identification of EDC: Methods 49
     
    Genetic Pathways 50
     
    Phosphorylation-Mediated Signaling Pathways of Nuclear Receptors and Other Transcription Factors: Link to EDC 53
     
    ER-Signaling Pathways 53
     
    Xenoandrogens and Metabolic Syndrome 54
     
    AR Signaling Pathways 54
     
    Mechanism of ED 55
     
    Methylation and Gene Regulation 55
     
    Role of Noncoding RNAs 59
     
    Transgenerational Inheritance of Epigenetics Induced by EDCs 59
     
    Anti-Thyroids 60
     
    Organotin 62
     
    Epigenetic Effects of Organotin 63
     
    TCDD and Related Compounds 63
     
    TCDD and Genetic Response 64
     
    TCDD-Mediated Epigenetic Response 65
     
    Conclusions 65
     
    References 66
     
    4 Nanoplastics in Agroecosystem and Phytotoxicity: An Evaluation of Cytogenotoxicity and Epigenetic Regulation 83
     
    Piyoosh Kumar Babele and Ravi Kant Bhatia
     
    Introduction 83
     
    Fate and Behavior of NPs in Agroecosystem and Soil Environment 85
     
    Uptake and Accumulation of NPs in Plants 87
     
    NPs and Phytotoxicity 88
     
    Can NPs Cause Cytogenotoxicity and Dysregulate Epigenetic Markers in Plants? 89
     
    NPs and Epigenetic Regulation 91
     
    Conclusion and Perspectives 92
     
    References 93
     
    5 Metal Oxide Nanoparticles and Graphene-Based Nanomaterials: Genotoxic, Oxidative, and Epigenetic Effects 99
     
    Delia Cavallo, Pieranna Chiarella, Anna Maria Fresegna, Aureliano Ciervo, Valentina Del Frate, and Cinzia Lucia Ursini
     
    Introduction 99
     
    Physicochemical Properties of NMs and Toxicity 100
     
    Mechanism of NM Genotoxicity 101
     
    Epigenetic Effects of Nanomaterials 102
     
    Studies on Genotoxic and Oxidative Effects of Metal Oxides and Graphene-Based Nanomaterials 104
     
    Graphene-Based NMs 120
     
    Studies on Epigenetic Effects of Metal Oxides and Graphene-Based Nanomaterials 123
     
    Studies on Workers - Genotoxic and Oxidative Effects of Occupational Exposure to Metal Oxides Nanoparticles, SiO2 NPs, and Graphene-Based Nanomaterials 127
     
    Conclusions 132
     
    References 132
     
    6 Epigenotoxicity of Titanium Dioxide Nanoparticles 145
     
    Carlos Wells, Marta Pogri