''A valuable resource for those concerned with experimental teratology and risk assessment and those requiring general information about the causes of birth defects. The treatment of these issues is sophisticated, succinct, and logical.'' --- American Scientist , from a review of a previous volume The current volume covers intergenerational factors in pregnancy outcome, the thresholds for developmental toxicants, and four other subjects.
''A valuable resource for those concerned with experimental teratology and risk assessment and those requiring general information about the causes of birth defects. The treatment of these issues is sophisticated, succinct, and logical.'' --- American Scientist, from a review of a previous volume The current volume covers intergenerational factors in pregnancy outcome, the thresholds for developmental toxicants, and four other subjects.
1 My Half-Life in Teratology: A Key to Cancer Etiology.- 1. Early Days.- 2. High School.- 3. College.- 4. Medical School.- 5. Internship.- 6. Residency.- 7. Radiobiology.- 8. Rochester.- 9. Japan.- 10. Washington.- 11. Michigan and Japan.- 12. Bethesda.- 13. The Study Section.- 14. The Teratology Society.- 15. U. S.-Japan Workshops.- 16. Short Sabbatical in Honolulu.- 17. Caracas.- 18. Professor Marois.- 19. National Childhood Cancer Death Registry.- 20. International Childhood Cancer Study.- 21. The Alert Clinician as Etiologist.- 22. Minamata Disease.- 23. Dioxin.- 24. Fetal Hydantoin Syndrome and Neuroblastoma.- 25. Chernobyl.- 26. The Clinical Epidemiology Branch.- 27. What Else?.- 28. In Perspective.- References.- 2 Intergenerational Factors in Pregnancy Outcome: Implications for Teratology?.- 1. Introduction.- 2. The Evidence for the Influence of Maternal Growth on Pregnancy Outcome.- 3. Intergenerational Factors in Neural Tube Defects.- 4. Other Evidence for Preconceptional Factors.- 5. Critical Period(s) of Maternal Growth.- 6. Clues to Possible Mechanisms Underlying the Intergenerational Phenomenon.- 7. The Pathway of the Intergenerational Phenomenon.- 8. Hypothetical Mechanisms Underlying the Intergenerational Phenomenon.- 9. Problems of Pregnancy Outcome in Perspective.- 10. Other Health Problems Related to Growth Retardation.- 11. Summary and Conclusions.- References.- 3 Epidemiological Studies of Congenital Abnormalities in Hungary.- 1. Concepts and Development.- 2. Descriptive Epidemiology.- 3. Analytical Epidemiology.- 4. Experimental Epidemiology.- 5. Conclusions.- References.- 4 A Contemporary Overview of Behavioral Teratology: A Perspective from the Field of Substance Abuse.- 1. Introduction.- 2. A Brief History.- 3. Changing Terms and Definitions.- 4.Methodological Issues in Animal Studies.- 5. Methadone: A Conflict of Paradigms.- 6. Cannabis, ?9-THC: The Role of Maternal Toxicity.- 7. The Cocaine Puzzle: Interpretive Issues in Human Studies.- 8. Conclusions.- References.- 5 Do Thresholds Exist for Developmental Toxicants? A Review of the Theoretical and Experimental Evidence.- 1. Introduction.- 2. Assessing Whether Thresholds Exist.- 3. Factors Contributing to Developmental Toxicity Thresholds.- 4. Individual and Population Heterogeneity in Susceptibility.- 5. Practical Solutions.- 6. Conclusions.- References.- 6 The History of His Life and Career.- 1. My Childhood.- 2. My Education.- 3. The Second World War Hiatus.- 4. Masters and Disciples.- 5. Single and Double Monstrosities.- 6. Hormonal Intersexuality among Birds.- 7. Organ Cultures in Vitro.- 8. Cancer Cultures.- 9. Regulation and Regeneration.- 10. My Travels Abroad and My Relationships with Scientists from Various Countries.- 11. The Academies.- 12. Retirement.
1 My Half-Life in Teratology: A Key to Cancer Etiology.- 1. Early Days.- 2. High School.- 3. College.- 4. Medical School.- 5. Internship.- 6. Residency.- 7. Radiobiology.- 8. Rochester.- 9. Japan.- 10. Washington.- 11. Michigan and Japan.- 12. Bethesda.- 13. The Study Section.- 14. The Teratology Society.- 15. U. S.-Japan Workshops.- 16. Short Sabbatical in Honolulu.- 17. Caracas.- 18. Professor Marois.- 19. National Childhood Cancer Death Registry.- 20. International Childhood Cancer Study.- 21. The Alert Clinician as Etiologist.- 22. Minamata Disease.- 23. Dioxin.- 24. Fetal Hydantoin Syndrome and Neuroblastoma.- 25. Chernobyl.- 26. The Clinical Epidemiology Branch.- 27. What Else?.- 28. In Perspective.- References.- 2 Intergenerational Factors in Pregnancy Outcome: Implications for Teratology?.- 1. Introduction.- 2. The Evidence for the Influence of Maternal Growth on Pregnancy Outcome.- 3. Intergenerational Factors in Neural Tube Defects.- 4. Other Evidence for Preconceptional Factors.- 5. Critical Period(s) of Maternal Growth.- 6. Clues to Possible Mechanisms Underlying the Intergenerational Phenomenon.- 7. The Pathway of the Intergenerational Phenomenon.- 8. Hypothetical Mechanisms Underlying the Intergenerational Phenomenon.- 9. Problems of Pregnancy Outcome in Perspective.- 10. Other Health Problems Related to Growth Retardation.- 11. Summary and Conclusions.- References.- 3 Epidemiological Studies of Congenital Abnormalities in Hungary.- 1. Concepts and Development.- 2. Descriptive Epidemiology.- 3. Analytical Epidemiology.- 4. Experimental Epidemiology.- 5. Conclusions.- References.- 4 A Contemporary Overview of Behavioral Teratology: A Perspective from the Field of Substance Abuse.- 1. Introduction.- 2. A Brief History.- 3. Changing Terms and Definitions.- 4.Methodological Issues in Animal Studies.- 5. Methadone: A Conflict of Paradigms.- 6. Cannabis, ?9-THC: The Role of Maternal Toxicity.- 7. The Cocaine Puzzle: Interpretive Issues in Human Studies.- 8. Conclusions.- References.- 5 Do Thresholds Exist for Developmental Toxicants? A Review of the Theoretical and Experimental Evidence.- 1. Introduction.- 2. Assessing Whether Thresholds Exist.- 3. Factors Contributing to Developmental Toxicity Thresholds.- 4. Individual and Population Heterogeneity in Susceptibility.- 5. Practical Solutions.- 6. Conclusions.- References.- 6 The History of His Life and Career.- 1. My Childhood.- 2. My Education.- 3. The Second World War Hiatus.- 4. Masters and Disciples.- 5. Single and Double Monstrosities.- 6. Hormonal Intersexuality among Birds.- 7. Organ Cultures in Vitro.- 8. Cancer Cultures.- 9. Regulation and Regeneration.- 10. My Travels Abroad and My Relationships with Scientists from Various Countries.- 11. The Academies.- 12. Retirement.
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