Knowledge of the early recognition of the unusual configurations facilitates a proper and successful cleaning, shaping and obturation of the canal system. This book summarizes all the necessary required protocols to be followed in successful management of such canal anatomies. In some instances, it may be difficult to distinguish between C-shaped canal or one with single or three canals joining apically. Thus, it is necessary to confirm the diagnosis by exploring the access cavity. Further long-term clinical studies are needed.