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The present endeavor embodies studies pertaining to the development of nitrogen containing fused ring systems as potential central nervous system active agents. The thesis has been organized into three sections, each section includes five chapters. The studies cover all the aspects of medicinal chemistry research, starting from synthetic organic chemistry to biological activity and eventually the molecular docking of active compounds. Few privileged scaffolds have been identified for the current study. One of them is 3-benzazepine, a seven membered bicyclic benzoannelated fused ring system.…mehr

Produktbeschreibung
The present endeavor embodies studies pertaining to the development of nitrogen containing fused ring systems as potential central nervous system active agents. The thesis has been organized into three sections, each section includes five chapters. The studies cover all the aspects of medicinal chemistry research, starting from synthetic organic chemistry to biological activity and eventually the molecular docking of active compounds. Few privileged scaffolds have been identified for the current study. One of them is 3-benzazepine, a seven membered bicyclic benzoannelated fused ring system. Several protocols have been reported in literature for the cyclization and substitution on 3-benzazepine scaffold. As focus of the study was to synthesize C-1 substituted 3-benzazepin-2-one scaffold, a direct arylation method was tried with the help of palladium chemistry.
Autorenporträt
Amit Verma was born in Lucknow, Uttar Pradesh, India. He graduated in Pharmacy (2004) and completed his M. Pharm. (2006) from UPTU, Lucknow, India. He did his PhD in Med Chem from MS Univ of Baroda and PostDoc from Freie Univ of Berlin. He has a vast exposure of medicinal chemistry research around the world and has guided several Masters and PhDs.