Obesity is a chronic disease, characterised by an excessive increase in body fat, which has a multifactorial aetiology including factors related to excessive intake of unhealthy foods, progressive reduction in physical activity, genetic, metabolic, social, behavioural and cultural factors Recently, the impact of obesity on male fertility has raised public interest in understanding the processes underlying this problem and, in this way, minimising harmful alterations to sexual function, such as erectile dysfunction. Erectile dysfunction is defined as the constant inability to achieve and/or maintain a penile erection sufficient for sexual satisfaction and is one of the health problems most feared by men. From a therapeutic point of view, it is possible to reverse this situation through surgical procedures, the use of devices that promote erection by vacuum, hormone replacement and the use of an arsenal of medicines. In this book, discover the pathophysiological interface between obesity and erectile dysfunction.