The purpose of this study was to examine the influence of psycho-social indicators of mathematics performance among secondary school students in Akpabuyo Local Government Area of Cross River State, Nigeria. Four null hypotheses were stated and tested at .05 level of significance using the Pearson Product Moment Correlation statistical technique A well validated 20- item Psycho-social indicators questionnaire and a 20 item performance test in Mathematics were designed and administered to the sample which was made up of 112 students. The analysis of data revealed that psycho-social factors such as family support problem, social environment problem, educational problem and economic problem has no significance influence on the academic performance of students in mathematics. Based on these findings, appropriate recommendations were made.