Restoration of Brain Function by Tissue Transplantation

Herausgegeben:Lindvall, Olle;Mitarbeit:Lindvall, Olle; Brundin, P.; Björklund, A.; Wictorin, K.; Dunnett, S. B.; Bengzon, J.; Gage, F. H.; Fisher, L. J.; Widner, H.

• Broschiertes Buch

Produktbeschreibung

Cell transplantation to the brain and spinal cord is awell-established research tool for studies on cellular andmolecular mechanisms, but can it be developed into a usefultherapuetic approach in human neurological disorders?Clinical trials in patients with Parkinson's disease haveprovided encouraging evidence, however, no treatment basedon transplantation is available yet. An overview of currentresearch is given in this book. It summarizes the status ofgrafting in humans and discusses scientific problems thathave to be solved before intracerebral transplantation canbecome a useful routine approach to treatment.

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Produktdetails

• Basic and Clinical Aspects of Neuroscience 5
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-540-55823-1
• Softcover reprint of the original 1st ed. 1993
• Seitenzahl: 88
• Erscheinungstermin: 25. Mai 1993
• Englisch
• Abmessung: 277mm x 210mm x 6mm
• Gewicht: 315g
• ISBN-13: 9783540558231
• ISBN-10: 3540558233
• Artikelnr.: 26966952

Inhaltsangabe

References.- Transplantation in Parkinson's Disease.- Experimental Studies in Animal Models of Parkinson's Disease.- Clinical Studies in Patients with Parkinson's Disease.- Research Strategies for the Development of a Transplantation Therapy in Parkinson's Disease.- Conclusions.- References.- Transplantation in Huntington's Disease: Experimental Basis and Clinical Perspectives.- Experimental Model.- Implants of Fetal Striatal Primordia.- Intrinsic Organization of the Striatal Grafts.- Biochemical Markers of Striatal Graft Maturation and Function.- Amelioration of Lesion-Induced Behavioral Deficits.- Mechanisms of Action of the Intrastriatal Grafts.- Afferent Regulation of the Grafted Neurons.- Trophic Effects of Striatal Transplants.- Studies in Primates.- Clinical Perspectives.- References.- Neural Transplantation in Dementia.- Common Terminology in Research on Alzheimer's Disease.- Models of Cholinergic Deficiency.- Models of Trophic Factor Deficiency.- Critical Neuropathology of Alzheimer's Disease.- Graft Models of the Cellular Pathology of Alzheimer's Disease.- Clinical Prospects in Dementia.- References.- Transplantation in Experimental Epilepsy.- Noradrenergic Grafts in Experimental Epilepsy.- Other Grafts in Experimental Epilepsy.- Present Lines of Research and Clinical Perspectives.- Concluding Remarks.- References.- Genetically Modified Cells for Intracerebral Transplantation.- Genetically Modified Cells and the Neurotrophic Strategy.- Genetically Modified Cells for Neurotransmitter Replacement.- Discussion and Future Directions.- References.- Immunologic Aspects of Intracerebral CNS Tissue Transplantation.- General Aspects of Transplantation Immunology.- The Brain as a Transplantation Site.- Immunologic Experience of IntracerebralTransplantation in Patients with Parkinson's Disease.- Conclusions.- References.