Study of Few Polysubstituted Piperidone Analogs

Study of Few Polysubstituted Piperidone Analogs

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Dipeptidyl Peptidase-IV (DPP-IV) was found to be one of the emerging targets in the field of antidiabetic drug development. In recent years, Piperidone analogs have shown their application in the field of diabetology as observed in the crystallographic structure of DPP-IV. All the ligand molecules were designed considering the pharmacophoric features of the GGO901 (Co-crystallised ligand of DPP-IV with the PDB entry-2OQI). It was thought worthwhile to perform docking study by extracting the crystallographic structure of Dipeptidyl Peptidase-IV inhibitor with all the virtually developed molecul...