Synthesis & anticancer activity of 1,3,4-thiadiazole derivatives
Synthesis of 2-[(Bis-(2-chloroethyl)amino)acetamido]-5-substituted-1,3,4-thiadiazole as possible anticancer agents
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Among the different alkylating agents, nitrogen mustards are proved to be more potent. Interesting pharmacological properties exhibited by 1,3,4-thiadiazoles prompted us to develop a simple method to synthesize a few nitrogen mustard derivatives, containing the above heterocyclic nucleus. This book provides information regarding the synthesis, purification and invitro invivo anticancer screening of the seven synthesized 1,3,4-thiadiazole derivatives.
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