Synthesis, Biological Activity and Characterization of New Hexahydro
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Sym-triazines have been documented for their antitumor, antimicrobial and anti-cancer action. The present work aims to derive a variety of 1,3,5-triaryl-1,3,5-hexahydro-s- triazines from the reaction of aryl-amines with aqueous formaldehyde. The preparation of the derivatives has been achieved according to the following steps: 1) The synthesis of the hexahydro-1,3,5-s-triazine (Ha), 2) The base catalyzed condensation of hexahydro-1,3,5-s-triazine (Ha), 3) The second hexahydro-1,3,5-s-triazine (Hb) is treated with hydrazine hydrate, 4) The reaction of carbohydrazide (Hb1) with formic acid, 5) T...
Sym-triazines have been documented for their antitumor, antimicrobial and anti-cancer action. The present work aims to derive a variety of 1,3,5-triaryl-1,3,5-hexahydro-s- triazines from the reaction of aryl-amines with aqueous formaldehyde. The preparation of the derivatives has been achieved according to the following steps: 1) The synthesis of the hexahydro-1,3,5-s-triazine (Ha), 2) The base catalyzed condensation of hexahydro-1,3,5-s-triazine (Ha), 3) The second hexahydro-1,3,5-s-triazine (Hb) is treated with hydrazine hydrate, 4) The reaction of carbohydrazide (Hb1) with formic acid, 5) The treatment of hydrazide (Hb1) with aliphatic and aromatic anhydrides, 6) The reaction of the triazine (Hb) with thiosemicarbazide in presence of Sodium acetate.
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