Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience Of Development:
I. Introductory Chapters: Setting The Scene For The Neuroscience Of Development
1. The brain and its structures: an overview; 2. Neural tube defects: embryonic origin, clinical features and cell survival equilibrium impact; 3. Chemical substances affecting neurodevelopment; 4. High-risk babies and Neurodevelopmental outcome; 5. Genomic Imprinting and neurodevelopment; 6. Insights from model systems: Alcohol, neurodevelopment and zebrafish; 7. Early life nutrition and brain development: maternal iodine nutrition and neurodevelopment; 8. Endocrine Aspects of Development. Thyroid hormone actions in neurological processes during brain development
II. Impairments and Diseases
9. Pediatric brain tumors; 10. Neurofibromatosis Type 1: from cellular phenotypes to human brain function; 11. The role and development of neural crest cells; 12. Spina Bifida: A Biopsychosocial Perspective; 13. Diabetic ketoacidosis and neurodevelopment; 14. Four-dimensional features of fetal brain: applications to diabetes; 15. Prenatally exposed to nicotine and neurodevelopment; 16. Maternal methamphetamine and impact on the brain; 17. Alcohol, cannabis and brain development; 18. The Environmental Pollutant Trichloroethylene Disrupts Key Neural Pathways During Brain Development; 19. Developmental neurotoxicity of the herbicide atrazine; 20. Neurodevelopmental delays and in utero hyperemesis gravidarum; 21. Neurodevelopment and Infantile Epileptic Encephalopathy-9 (EIEE9); 22. Neurodevelopment in Turner syndrome; 23. Very preterm children and the impact on neurodevelopmental outcomes; 24. Linking congenital heart disease and brain functional connectivity in newborns; 25. Brain Growth in Congenital Heart Disease from Prenatal Environment to Adulthood; 26. Linking dopamine, amphetamine and neurodevelopment; 27. Developmental coordination disorder
III. Biomarkers, Screening, Methods and Diagnosis
28. Neurodevelopment and the The Ages and Stages Questionnaire, third edition (ASQ-3); 29. Screening for Attention Deficit Hyperactivity Disorder in children; 30. The Mini-Mental State Pediatric Examination screening tool: Italian perspectives; 31. Predictors of neurodevelopment in preterm infants: from the neonatal intensive care unit into adulthood; 32. The antenatal fetal neurodevelopmental test: uses and applications
IV: Management and Treatments
33. Pain, evaluation and management in neurodevelopmental conditions; 34. Use of levetiracetam: Features and applications to neonatal seizures; 35. Quetiapine treatment in paediatric scenarios; 36. Treatments with cannabinoids and brain development; 37. Pediatric dystonia and deep brain stimulation; 38. Use of repetitive transcranial magnetic stimulation in neurodevelopment: a narrative review; 39. Cognitive behavioral therapy in children with anxiety disorders; 40. Cognitive behavioral therapy for anxiety in children with autism spectrum disorder; 41. Nutritional treatment in fetal alcohol spectrum disorder; 42. Nurturing the Developing Brain to Reduce Neurological Delay; 43. Normalizing perinatal neurological development via intervention
V. Models And Modelling
44. Microplatforms as a Model for Neurological Conditions; 45. Disease models in neurodevelopmental disorders; 46. Endosulfan and impact on neurodevelopment: modelling with zebrafish (Danio rerio); 47. Neurodevelopment of the zebrafish spinal serotonin system; 48. Inbred mouse model of brain development and intestinal microbiota; 49. The myelin mutant taiep rat as a model of developmental disorder; 50. The MAM-E17 neurodevelopmental model of schizophrenia
VI. Resources
51. Research and recommended resources in the neuroscience of development
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Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet:
I. Genetics, Molecular and Celluar Biology
1. Hereditary motor neuropathies; 2. Dopamine transporter (DAT1) polymorphism and development; 3. Genome wide association studies (GWAS) and neurodevelopment: Autism spectrum disorder; 4. SNPs and cerebral palsy; 5. Epigenetic regulation of cortical neurogenesis; 6. Functions and dynamics of axonal mitochondria; 7. Linking apoptosis and caspases in fetal neural tube defects; 8. Brain oxidative stress in Down syndrome; 9. Linking Adhesion GPCRs to Glial Cell Development and Function; 10. Immunoglobulin cell adhesion molecule superfamily and neurodevelopment; 11. Brain-derived neurotrophic factor (BDNF) and neurogenesis; 12. slc7a5 and neural development; 13. Linking SOX3, SRY and disorders of neurodevelopment; 14. Neuronal Src-homology-2 (SH2)B adaptor protein-1 (Sh2b1) and brain growth; 15. Effects of extrinsic factors and intracellular signalling and transcription factors regulating the development and
cell fate of spinal cord ependymal cells; 16. Signaling molecules controlling oligodendrocyte development and brain myelination
II. Neurological and Imaging Features
17. Fetal brain structures: imaging oriented; 18. Four-dimensional (4D) ultrasonography: Methods, uses and fetal neuroscience; 19. Linking histology and neurological development of the fetal and infant brain; 20. Development of Corticospinal tract axons: from embryonic stage to adulthood; 21. Vascular endothelial growth factor (VEGF) and neurodevelopment; 22. Brain-wide connectivity architecture: developmental aspects; 23. Development and pathology of the germinal matrix; 24. Development of the GABAergic network in the mouse spinal cord; 25. Postnatal development, electrophysiology and sensory sural nerves; 26. Neuroscience of the developing axonal strata in the human fetal brain; 27. Neuroactive steroids and neurodevelopment; 28. Voltage and ligand-gated ion channels appearance and function in neurodevelopment; 29. Features of brain development over 13 years in preterms; 30. The medial pulvinar in neurodevelopment; 31. Cortical sulci in the human fetal brain and development; 32. The prenatal development of the human cerebellum; 33. Developing cerebello-cerebral connectivity in health and disease: a focus on epilepsy; 34. Prenatal exposure to progestins: impact on neurodevelopment of the child
III. Physiological Aspects
35. Brain lesion characteristics in relation to upper limb function in children with unilateral cerebral palsy; 36. Maternal exercise and brain development; 37. Pyramidal neurons: physiology, Pathophysiology and postnatal development; 38. Working memory: physiology and neurodevelopment; 39. EEG development in resting states; 40. Availability and metabolism of thyroid hormones in the developing brain
IV. Behavior And Psychopathological Aspects
41. Psychosocial issues and quality of life following childhood stroke; 42. Neuropsychological function following childhood stroke; 43. Youths with autism and working memory; 44. Linking the mesial temporal lobe, 3D probabilistic maps and development; 45. Cognitive aspects of Down Syndrome; 46. Adolescent cannabis use and neurocognitive development; 47. The Role of Social Anxiety in Autism and the Broader Autism Phenotype: Evidence from Childhood through Adulthood; 48. Impact of touch on bonding and neurodevelopment; 49. Neurobehaviour and catch up growth
V. Diet And Nutrition
50. Caloric restriction and the developing brain; 51. High-fat diet, tryptophan hydroxylase-2 mRNA expression and neurodevelopment; 52. Bone mineral density and nutritional status in children with cerebral palsy; 53. Epigallocatechin-3-gallate: linking the neurogenesis, hippocampus and Down syndrome; 54. Folic acid-to prevent spina bifida and anencephaly
