1 Complement as a Regulatory and Effector Pathway in Human Diseases.- 2 The Regulation of C1 Activation and its Role in Disease.- 3 Inhibition of Complement Serine Proteases as a Therapeutic Strategy.- 4 Complement Inhibitors Targeting C3, C4, and C5.- 5 Complement Anaphylatoxins (C3a, C4a, C5a) and Their Receptors (C3aR, C5aR/CD88) as Therapeutic Targets in Inflammation.- 6 Modulation of Disease Using Recombinant Human Endogenous Complement Inhibitors.- 7 Roles of Integrins CR3 and CR4 in Disease and Therapeutic Strategies.- 8 Inhibition of Complement in the Membrane Attack Pathway.- 9 Evaluation of Complement Inhibitors.- 10 Use of Animal Models to Define Complement Functions.