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The only sweetness that we don't want in life is glucose in our body. For diabetic patients, sweetness in blood and bitterness (complications in the body) in mind are the positive correlation factors. Eye is the major organ that is highly targeted by diabetes. Clinically known by diabetic retinopathy, it damages the blood vessels, deregulates the expression of genes, then alters the pathways and so develops the pathogenesis - BLINDNESS. We can attack retinopathy with medical treatment, only it acts as safe guard, but not as healer; and results side effects on vision. Even though so many advancements are in the medical field, still many factors are behind the screen - genesis, development, severity and cause of the disease are still not clear. This book gives you the perspectives of diabetic retinopathy that currently known, different ways to look at the disease, analytical report based on Bioinformatic approaches. Hope this may enlighten the new idea to deal the diabetic retinopathy.