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High Quality Content by WIKIPEDIA articles! Statistical parametric mapping or SPM is a statistical technique for examining differences in brain activity recorded during functional neuroimaging experiments using neuroimaging technologies such as fMRI or PET. It may also refer to a specific piece of software created by the Wellcome Department of Imaging Neuroscience (part of University College London) to carry out such analyses. Functional neuroimaging, one type of 'brain scanning', involves the measurement of brain activity. The specific technique used to measure brain activity depends on the imaging technology being used (see fMRI and PET for examples). Regardless of which technology is used, the scanner produces a 'map' of the area being scanned that is represented as voxels.