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High Quality Content by WIKIPEDIA articles! X-linked hyper-immunoglobulin M syndrome is an inherited condition characterized by recurrent sinopulmonary and GI infections with pyogenic bacteria and opportunistic organisms, a disease which may have cutaneous manifestations including pyodermas extensive warts. Immunodeficiency with hyperimmunoglobulin M is a rare disorder characterized by recurrent infections, low or absent IgG, IgE, and IgA levels, and normal or elevated levels of IgM and IgD. There are many conditions of or affecting the human integumentary system the organ system that covers the entire surface of the body and is composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment.